After completing a PhD on complex polar organometallic compounds in Nancy in 2007, Estelle Léonard pursued postdoctoral research in asymmetric catalysis at the University of Birmingham from 2006 to 2007. She then joined the CNRS in Le Mans, where she worked from 2007 to 2008 on photochromic molecules designed for health-related applications. Building on this expertise, she later focused on the development of photochromic systems with antibacterial properties.

She is currently a researcher at the TIMR Laboratory (UTC-ESCOM), where her work explores innovative molecular strategies for controlling bacterial activity (HDR). Her research combines dyes synthetic chemistry, photochemistry, and materials science to address emerging public-health challenges. Over the years, she has contributed to several collaborative projects involving both academic and industrial partners. Her scientific activities reflect a sustained commitment to innovation in functional molecular systems. In addition to her research, she regularly participates in outreach and knowledge-transfer initiatives. She was appointed as a member of the Conseil supérieur de la prévention des risques technologiques (CSPRT), where she represents consumer interests. Through this role, she contributes her scientific perspective to national discussions on technological risk management.