Karine Lacombe, M.D, PhD, is an infectious diseases specialist whose clinical practice, teaching and research are focusing on viral infections. She graduated from Pierre et Marie Curie Medical University in Paris and completed her residency in St Antoine Hospital, Paris and St André Hospital, Bordeaux. In 2006, she got her PhD in Epidemiology on HIV / hepatitis B coinfection and the determinants of liver fibrosis. She became an associate Professor in Infectious Diseases in 2007 and got a full professorship position at Sorbonne Universite in 2016. Recent publications include results of phase 2 and 3 clinical trials in HIV, chronic hepatitis as well as respiratory viral infections. She is one of the international leaders in chronic viral infections and has been giving plenary lectures in all international conferences in infectious diseases. Since March 2020, she has been deeply involved as a clinician and researcher but also at a political level in the management of the Covid-19 crisis. As a specialist in epidemiology and methodology of phase 1 to 3 clinical trials, she is also involved in the development of numerous innovative drugs for clinical stage - biochtech companies. Presently, she is coordinating the PROACT in EU-RESPONSE adaptive platform trials which has recently been funded by the Horizon EU call. She is the head of the Infectious Diseases Department in St Antoine Hospital, AP-HP, Paris, and supervises the clinical research commission of the Board of Physicians of AP-HP.